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Adaptive optics scanning laser ophthalmoscope (AOSLO) - UH
  • Under construction as of May 07
  • Description: uses adaptive optics technology with confocal focusing capabilities to correct optical imperfections in the human eye and noninvasively obtain images of individual cells in the living retina with a lateral resolution (~ 2 microns) that is at least 2 to 4 times better than that of current clinical instruments. This instrument will provide real-time imaging of the retina in depth along with significant improvements in retinal image contrast due to the use of a confocal aperture that rejects light scattered from objects outside the plane of focus. Also, the addition of fluorescence imaging capabilities will allow normally transparent cells (such as ganglion cells) that are labeled with a fluorescent marker to emit visible light (or fluoresce) when exposed to certain wavelengths of light. Imaging individual cells in the living eye could enhance our ability to better understand and diagnose blinding retinal diseases, such as glaucoma and different macular degenerations, and importantly, to track the effectiveness of potential treatments, such as precision laser surgery and gene therapies.
  • PI: Jason Porter